At GreenBone®, we are a group of innovators and scientists, all of whom have experience in taking products from ideas to the market. In 2014 Greenbone® Ortho S.p.A. was established to search for answers to unmet clinical needs in orthopaedic surgery where bone reconstruction is necessary following any number of traumatic, surgically induced, chronic and degenerative conditions. Going beyond conventional thinking, we decided to develop an innovative technology by looking to nature for inspiration and radical answers.


From its start, GreenBone® Ortho S.p.A. chose to use nature as the best model for its products. In particular, by using wood as a precursor, it is possible to mimic the original structure and porosity of wood in the finished implant (b.Bone™).

Dr. Anna Tampieri, Director of the Institute of Science and Technology for Ceramics – National Research Council (ISTEC-CNR) in Faenza, Italy had already developed a chemical process for biomorphic transformation involving rattan wood to create biomimetic and regenerative implants designed to develop strong, new bone.

By collaborating closely with ISTEC-CNR and Dr. Anna Tampieri, GreenBone® was able to transition this technology from the laboratory to the market quickly and efficiently. To support this and meet expected capacity demands, in 2021 GreenBone® opened a manufacturing facility in Roncadelle (BS) in Northern Italy.


Our first thought was to understand that the three-dimensional bone structure was mimicked in the rattan structure. The key breakthrough was devising a proprietary biotransformation process that avoided the need for sintering. As a result, we eliminated the main barrier to bone regeneration while creating a natural, versatile and effective procedure. It will become every surgeon’s natural, first choice.

Greenbone® Ortho S.p.A. is constantly searching for innovation, new applications for its product, and clinical evidence. For this reason, we collaborate closely with Research Institutes, Universities, and internationally well recognized Key Opinion Leaders to improve patients outcomes.


The original research by Dr. Tampieri at ISTEC-CNR had identified rattan as the ideal material for turning wood into b.Bone™ since it possesses extensive longitudinal pores that, in the finished implant, allow for bone regeneration. 

Our unique manufacturing process starts by removing all plant materials from the rattan. Subsequent steps – named biomorphic transformation - transform the wood into a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) preserving its porous architecture and producing a structure similar to that found in normal, healthy bone. This porosity acts like Haversian canals throughout the whole graft, allowing vascularization and the necessary exchange of biological fluids to support bone regeneration.

The biomorphic transformation process using to create b.Bone™ achieves its final chemical composition of HA and PCP without the need for high temperature sintering as is required for other ceramic implants. As a result, b.Bone™ possesses a nanocrystalline structure that supports increased mineralization of the regenerated new bone. This process has been extensively patented around the world.

b.Bone™ is available in a wide range of shapes and sizes: cylinder, block, wedge and granules to match clinical applications including: Traumatology, Bone Augmentation, Joint Augmentation, Correction of Deformity, Lenghtening, Non Union, Bone Loss, Osteotomy, Joint Revision. 


  • Unique internal 3D architecture from wood;
  • No sintering process to preserve hydroxyapatite bioactivity;
  • Enhanced bone regeneration;
  • Biocompatible and safe;



  • b.Bone™ can be easily shaped inter-operatively to mimic any type of bone defect and achieve a better fit;
  • Enhanced mineralization of the resultant new bone;
  • Better fluid imbibition, including bone marrow aspirate, due to the micro- and macro porosity;



b.Bone™ is characterized by phase composition of Hydroxyapatite (HA) 85±10 % and Beta-Tricalcium Phosphate (β-TCP) 15±10 %. Architecture is engineered with a porous geometry and interconnected porosity to reflect the anatomical and physiological hierarchical structure of human bone



Rattan is a naturally renewable palm that grows in the tropical regions of Africa and Asia and it has multiple uses, such as for furniture, handicrafts and building material. Rattan grows climbing and winding itselves around other vegetation, some varieties growing lengths of more than 100m in length. The innumerable pinnate leaves, which extend up to 7 m or more in length play a major role in intercepting the plash effect of rain and in enriching the soil by their leaf litter, which adds to the organic content of the soil. Harvesting rattan can be a sustainable way for local people to make a living. Rattan supports a global industry worth more than US$4 billion a year . Because it needs trees to grow, rattan can provide an incentive for communities to conserve and restore the forest on their land. Calamus Manna – rattan wood - from Malaysia was chosen for its microstructural characteristics similar to spongy bone (Ruffini et al. 2013). This rattan wood was selected as a bone model for its outstanding similarity with the structure of osteons, which constitute a main functional unit of the long bone hierarchical architecture (Ruffini et al. 2021).