Innovation to enhance bone healing

b.Bone is a radically new innovative 3D bone replacement

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b.Bone

is an innovative bioactive and biomimetic bone substitute that mirrors the structure of natural bone.

b.Bone is composed of hydroxyapatite and beta-tricalcium phosphate in a unique, highly interconnected and porous 3D structure which mimics the hierarchical architecture and morphology of natural human bone.

greenbone_ortho_bbone_cylinder_bone_regeneration

greenbone_ortho_bbone_blocks_bone_regeneration

greenbone_ortho_bbone_wedge_bone_regeneration

greenbone_ortho_bbone_granules_bone_regeneration

Typical human bone structure. Scale 200 μm

b.Bone structure. Scale 200 μm

This biomimetic structure of b.Bone promotes new bone formation and remodeling. b.Bone ‘s biomimetic properties facilitate cellular infiltration and vascularization throughout the graft material for natural bone healing, as well as ensuring bio-resorption.

b.Bone is intended for use as a bone graft for voids or gaps that are not intrinsic to the stability of the bony structure.

It is indicated in the treatment of surgically created osseous defects or osseous defects resulting from traumatic injury to the bone.
b.Bone is intended to be implanted into bony voids or gaps of the skeletal system as a bone substitute, in the extremities and pelvis.

Principal Features

Biomimetic

Bone-mimicking hierarchical structure of human bone

Designed to provide natural bone healing and optimal bone quality
Promoting bone healing by supporting cell homing and differentiation

Bioactive

Bioactive composition and nanostructure

HA and β-TCP components with the presence of CO₃^2-, Mg ²⁺ and Sr²⁺ reflect the composition of bone
The unique structure combining the nanostructural properties and the chemical composition similar to human bone facilitate crosstalk between cells in the signaling pathway to enhance bone healing

ADVANTAGES

Unique composition with biomorphic HA

Chemical composition, porosity and pore size distribution are relevant for the biologic performance because they are key aspects for cell adhesion, new bone formation and osteointegration.

Open-pore geometries with highly porous surfaces and microstructures allowing cell in-growth and reorganization and providing the necessary space for vascularization.

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ADVANTAGES

Osteoinductive properties (1)

Dynamic exchange of information with physiological systems to drive bone cell regeneration.

The bone-like matrix and 3D porus is ideal to allow the natural bone healing process and the formation of a morphologically well-organized new bone tissue.

1. Results from in vivo laboratory testing. Performance in humans has not yet been established.

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ADVANTAGES

Unrivaled ease of use

b.Bone can be easily customized in the operating room by the surgeon to achieve the best fit to restore the anatomy of the patient.

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ADVANTAGES

Manufactured in several shapes and different sizes

To support surgeon’s techinque and orthopedic procedures, including challenging bone defect.

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ADVANTAGES

Totaly safe and biocompatible

The biomorphic transformation of rattan wood into b.Bone is a patented technology resulting into a safe substitute.

Our proprietary method of biomorphic transformation from wood allows us to obtain a biocompatible bone substitute in accordance to ISO 10993 standards.

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ADVANTAGES

Vegetal origin

b.Bone is not just natural, it is vegan. So it has no cultural, religious or dietary issues to manage.

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ADVANTAGES

Supported by scientific, pre-clinical and clinical studies

Results demonstrate the formation of well organized and performing remodelled bone in a clinically relevant timeframe.

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ADVANTAGES

Proprietary manufacturing process

The novel multi-step patented process transforms vegetable structures into biomaterial maintaining the morphology and hierarchical architecture of the rattan wood with unidirectional oriented pore structures on
the submicrometer dimensions.

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Product family

Wide range of shapes and sizes: cylinders, blocks, wedges and granules to match clinical applications

Cylinders

b.Bone™ is intended for use as a bone graft for voids or gaps that are not intrinsic to the stability of the bony structure. It is indicated in the treatment of surgically created osseous defects or osseous defects resulting from traumatic injury to the bone.

b.Bone™ is intended to be implanted into bony voids or gaps of the skeletal system as a bone substitute, in the extremities and pelvis.

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Product code	Outer diameter (OD)	Inner diameter (ID)	Length (L)
HC100010PS*	10 mm	0 mm	10 mm
HC100020PS*	10 mm	0 mm	20 mm
HC100030PS	10 mm	0 mm	30 mm
HC100040PS*	10 mm	0 mm	40 mm
HC100050PS*	10 mm	0 mm	50 mm
HC100060PS	10 mm	0 mm	60 mm
HC150610PS*	15 mm	6 mm	10 mm
HC150620PS*	15 mm	6 mm	20 mm
HC150630PS	15 mm	6 mm	30 mm
HC150640PS*	15 mm	6 mm	40 mm
HC150650PS*	15 mm	6 mm	50 mm
HC150660PS	15 mm	6 mm	60 mm
HC201010PS*	20 mm	10 mm	10 mm
HC201020PS*	20 mm	10 mm	20 mm
HC201030PS	20 mm	10 mm	30 mm
HC201040PS*	20 mm	10 mm	40 mm
HC201050PS*	20 mm	10 mm	50 mm
HC201060PS	20 mm	10 mm	60 mm
HC251310PS*	25 mm	13 mm	10 mm
HC251320PS*	25 mm	13 mm	20 mm
HC251330PS	25 mm	13 mm	30 mm
HC251340PS*	25 mm	13 mm	40 mm
HC251350PS*	25 mm	13 mm	50 mm
HC251360PS	25 mm	13 mm	60 mm
HC301510PS*	30 mm	15 mm	10 mm
HC301520PS*	30 mm	15 mm	20 mm
HC301530PS	30 mm	15 mm	30 mm
HC301540PS*	30 mm	15 mm	40 mm
HC301550PS*	30 mm	15 mm	50 mm
HC301560PS	30 mm	15 mm	60 mm

*Upon request

Blocks

b.Bone™ is intended to be implanted into bony voids or gaps of the skeletal system as a bone substitute, in the extremities and pelvis.

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Product code	Width (W)	Depth (D)	Height (H)
HP401020PS	10 mm	20 mm	40 mm
HP200510PS*	5 mm	10 mm	20 mm
HP200520PS*	5 mm	20 mm	20 mm
HP200530PS*	5 mm	30 mm	20 mm
HP201010PS*	10 mm	10 mm	20 mm
HP201020PS*	10 mm	20 mm	20 mm
HP201030PS*	10 mm	30 mm	20 mm
HP201510PS*	15 mm	10 mm	20 mm
HP201520PS*	15 mm	20 mm	20 mm
HP201530PS*	15 mm	30 mm	20 mm
HP300510PS*	5 mm	10 mm	30 mm
HP300520PS*	5 mm	20 mm	30 mm
HP300530PS*	5 mm	30 mm	30 mm
HP301010PS*	10 mm	10 mm	30 mm
HP301020PS*	10 mm	20 mm	30 mm
HP301030PS*	10 mm	30 mm	30 mm
HP301510PS*	15 mm	10 mm	30 mm
HP301520PS*	15 mm	20 mm	30 mm
HP301530PS*	15 mm	30 mm	30 mm
HP400510PS*	5 mm	10 mm	40 mm
HP400520PS*	5 mm	20 mm	40 mm
HP400530PS*	5 mm	30 mm	40 mm
HP401010PS*	10 mm	10 mm	40 mm
HP401030PS*	10 mm	30 mm	40 mm
HP401510PS*	15 mm	10 mm	40 mm
HP401520PS*	15 mm	20 mm	40 mm
HP401530PS*	15 mm	30 mm	40 mm
HP500510PS*	5 mm	10 mm	50 mm
HP500520PS*	5 mm	20 mm	50 mm
HP500530PS*	5 mm	30 mm	50 mm
HP501010PS*	10 mm	10 mm	50 mm
HP501020PS*	10 mm	20 mm	50 mm
HP501030PS*	10 mm	30 mm	50 mm
HP501510PS*	15 mm	10 mm	50 mm
HP501520PS*	15 mm	20 mm	50 mm
HP501530PS*	15 mm	30 mm	50 mm

*Upon request

Wedges

b.Bone™ is intended to be implanted into bony voids or gaps of the skeletal system as a bone substitute, in the extremities and pelvis.

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Product code	Depth (D)	Width (W)	Angle (α)
WE093015PS	30 mm	15 mm	9°
WE113015PS	30 mm	15 mm	11°
WE133015PS	30 mm	15 mm	13°
WE094030PS	40 mm	30 mm	9°
WE114030PS	40 mm	30 mm	11°
WE134030PS	40 mm	30 mm	13°

Granules

b.Bone™ is intended to be implanted into bony voids or gaps of the skeletal system as a bone substitute, in the extremities and pelvis.

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Product code	Size range	Quantity
GR051015PS	0,5 - 1 mm	5 g
GR102015PS	1 - 2 mm	5 g
GR204015PS	2 - 4 mm	5 g
GR407115PS	4 - 7,1 mm	5 g